Some people make fun of those who hear about a terrible disease and begin to believe that they suffer from it. Among the sufferers are peple who develop symptoms of the conditions they fear that they have.

https://www.youtube.com/watch?v=HipJ6szfxaM&ab_channel=Technion

Are these feelings all in your head? It is possible that there are neurons in the brain that can create a sensation of illness or even an actual disease – a self-fulfilling prophesy?

Psychosomatic disorders are described as diseases emerging with no apparent biological cause, and they often include a strong emotional component as a trigger. In a study recently published in the journal Cell under the title “Insular cortex neurons encode and retrieve specific immune responses,” scientists at the Technion-Israel Institute of Technology in Haifa investigated the brain’s potential to cause diseases on its own. Specifically, they induced inflammation in mice and then triggered the neurons in the brain that were active during the initial inflammation.

The study was conducted by the research group of Associate Prof. Asya Rolls from the Rappaport Faculty of Medicine, led by Tamar Koren, an M.D./Ph.D. student in the lab. The study was carried out in collaboration with Dr. Kobi Rosenblum of the University of Haifa and Dr. Fahed Hakim, of EMMS Hospital in Nazareth. 

They showed that when the colon is inflamed, several brain regions exerted enhanced neuronal activity, one of which was the insular cortex (insula). The insula is an area in the brain responsible for interoception, that is the sense of the body’s physiological state. This includes hunger, thirst, pain, and heart rate. 

The researchers suggested that if a report of inflammation in some part of the body is stored somewhere in the brain, this area responsible for interoception would be involved. 

Armed with this hypothesis, they induced in mice an inflammation in the colon and using genetic manipulation techniques, “captured” groups of neurons in the insular cortex that showed increased activity during the inflammation. Once the mice were healthy, the researchers triggered these “captured” neurons artificially. Without any outside stimulus other than this triggering of cells in the brain, inflammation re-emerged, in the exact same area where it was before. “Remembering” the inflammation was enough to reactivate it. 

If the brain can generate disease, is it possible that it can also turn it off? 

In a similar manner, Koren also demonstrated the opposite effect – in mice with active inflammation, suppressing the neurons that remembered it produced an immediate reduction in the inflammation. Although this was a basic study in mice, and there are multiple challenges in translating the concept to humans, these discoveries open a new therapeutic avenue for treating chronic inflammatory conditions such as Crohn’s disease, psoriasis and other autoimmune conditions by weakening their memory trace in the brain. 

“There are evolutionary advantages to such a connection,” said Rolls, explaining the strange phenomenon whereby the immune system should be activated by memory alone, without an outside trigger. “The body needs to respond to infection as quickly as possible before the attacking bacteria or viruses can multiply. If certain activity, for example consuming particular foods, has exposed the body to infection and inflammation once, there is an advantage to gearing up for battle when one is about to engage in the same activity again. A shorter response time would allow the body to defeat the infection faster and with less effort. The problem of course is when such an effective mechanism goes out of control and can on its own generate the disease.”

The group’s findings have broad implications for understanding the way the human mind and body affect each other, but also more immediate implications for understanding and treating illness with a psychosomatic element, like irritable bowel syndrome and even autoimmune diseases and allergies.

Technion scientists explore the brain’s potential to cause diseases on its own. Specifically, they induced inflammation in mice, and then triggered the neurons in the brain that were active during the initial inflammation.

The study was conducted by the research group of Associate Professor Asya Rolls from the Technion Ruth and Bruce Rappaport Faculty of Medicine, led by Tamar Koren, an M.D./Ph.D. student in the lab. They showed that during colon inflammation, several brain regions exert enhanced neuronal activity, one of which was the insular cortex (insula). The insula is an area in the brain responsible for interoception, that is the sense of the body’s physiological state. This includes hunger, thirst, pain, and heart rate. 

The researchers postulated that if report of inflammation in some area of the body is stored somewhere in the brain, this area responsible for interoception would be involved. Armed with this hypothesis, they induced in mice an inflammation in the colon and using genetic manipulation techniques, “captured” groups of neurons in the insular cortex that showed increased activity during the inflammation. Once the mice were healthy, the researchers triggered these “captured” neurons artificially. Without any outside stimulus other than this triggering of cells in the brain, inflammation re-emerged, in the exact same area where it was before. “Remembering” the inflammation was enough to reactivate it. 

If the brain can generate disease, is it possible that it can also turn it off? 

In a similar manner, Tamar also demonstrated the opposite effect: in mice with active inflammation, suppressing the neurons that remembered it produced an immediate reduction in the inflammation. Although this was a basic study in mice, and there are multiple challenges in translating the concept to humans, these discoveries open a new therapeutic avenue for treating chronic inflammatory conditions such as Crohn’s disease, psoriasis, and other autoimmune conditions, by attenuating their memory trace in the brain. 

“There are evolutionary advantages to such a connection,” said Prof. Rolls in explaining the strange phenomenon whereby the immune system should be activated by memory alone, without an outside trigger. “The body needs to respond to infection as quickly as possible before the attacking bacteria or viruses can multiply. If certain activity, for example consuming particular foods, has exposed the body to infection and inflammation once, there is an advantage to gearing up for battle when one is about to engage in the same activity again. A shorter response time would allow the body to defeat the infection faster and with less effort. The problem of course is when such an effective mechanism goes out of control and can on its own generate the disease.”

The group’s findings have broad implications for understanding the way the human mind and body affect each other, but also more immediate implications for understanding and treating illness with a psychosomatic element, like irritable bowel syndrome and even autoimmune diseases and allergies.